6SLO

Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine

Summary for 6SLO

Entry DOI	10.2210/pdb6slo/pdb
Descriptor	Thioredoxin,Poly(U)-binding-splicing factor PUF60, MAGNESIUM ION, 2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, ... (4 entities in total)
Functional Keywords	uhm domain, splicing inhibitor, splicing
Biological source	Citrobacter freundii MGH 56 More
Total number of polymer chains	4
Total formula weight	99664.37
Authors	Jagtap, P.K.A.,Kubelka, T.,Bach, T.,Sattler, M. (deposition date: 2019-08-20, release date: 2020-09-09, Last modification date: 2024-01-24)
Primary citation	Jagtap, P.K.A.,Kubelka, T.,Soni, K.,Will, C.L.,Garg, D.,Sippel, C.,Kapp, T.G.,Potukuchi, H.K.,Schorpp, K.,Hadian, K.,Kessler, H.,Luhrmann, R.,Hausch, F.,Bach, T.,Sattler, M. Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly. Nat Commun, 11:5621-5621, 2020 Cited by PubMed: 33159082 DOI: 10.1038/s41467-020-19514-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation