6SLO

Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine

6SLO の概要

• エントリーDOI: 10.2210/pdb6slo/pdb
• 分子名称: Thioredoxin,Poly(U)-binding-splicing factor PUF60, MAGNESIUM ION, 2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, ... (4 entities in total)
• 機能のキーワード: uhm domain, splicing inhibitor, splicing
• 由来する生物種: Citrobacter freundii MGH 56; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 99664.37

構造登録者

Jagtap, P.K.A.,Kubelka, T.,Bach, T.,Sattler, M. (登録日: 2019-08-20, 公開日: 2020-09-09, 最終更新日: 2024-01-24)

• 主引用文献: Jagtap, P.K.A.,Kubelka, T.,Soni, K.,Will, C.L.,Garg, D.,Sippel, C.,Kapp, T.G.,Potukuchi, H.K.,Schorpp, K.,Hadian, K.,Kessler, H.,Luhrmann, R.,Hausch, F.,Bach, T.,Sattler, M.; Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.; Nat Commun, 11:5621-5621, 2020; PubMed: 33159082; DOI: 10.1038/s41467-020-19514-1

実験手法

X-RAY DIFFRACTION (1.94 Å)