6SKH

X-ray structure of human glutamate carboxypeptidase II (GCPII) - the E424M inactive mutant, in complex with a inhibitor sulfamide inhibitor GluAsp

6SKH の概要

• エントリーDOI: 10.2210/pdb6skh/pdb
• 分子名称: Glutamate carboxypeptidase 2, CHLORIDE ION, beta-D-mannopyranose, ... (15 entities in total)
• 機能のキーワード: glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; sulfamide, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 84329.36

構造登録者

Motlova, L.,Novakova, Z.,Barinka, C. (登録日: 2019-08-15, 公開日: 2020-08-26, 最終更新日: 2024-01-31)

• 主引用文献: Novakova, Z.,Tehrani, Z.A.,Jurok, R.,Motlova, L.,Kutil, Z.,Pavlicek, J.,Shukla, S.,Choy, C.J.,Havlinova, B.,Baranova, P.,Berkman, C.E.,Kuchar, M.,Cerny, J.,Barinka, C.; Structural, Biochemical, and Computational Characterization of Sulfamides as Bimetallic Peptidase Inhibitors.; J.Chem.Inf.Model., 2024; PubMed: 38224368; DOI: 10.1021/acs.jcim.3c01542

実験手法

X-RAY DIFFRACTION (1.58 Å)