6SKD
Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3397892A
Summary for 6SKD
Entry DOI | 10.2210/pdb6skd/pdb |
Descriptor | Kallikrein-6, UNKNOWN ATOM OR ION, 4-[[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]methylamino]benzenecarboximidamide, ... (5 entities in total) |
Functional Keywords | protease, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 49709.90 |
Authors | Thorpe, J.H. (deposition date: 2019-08-15, release date: 2019-09-25, Last modification date: 2024-01-24) |
Primary citation | Walker, A.L.,Denis, A.,Bingham, R.P.,Boulliot, A.,Edgar, E.V.,Ferrie, A.,Holmes, D.S.,Laroze, A.,Liddle, J.,Fouchet, M.H.,Moquette, A.,Nassau, P.,Pearce, A.C.,Polyakova, O.,Smith, K.J.,Thomas, P.,Thorpe, J.H.,Trottet, L.,Wang, Y.,Hovnanian, A. Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. Bioorg.Med.Chem.Lett., 29:126675-126675, 2019 Cited by PubMed: 31521475DOI: 10.1016/j.bmcl.2019.126675 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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