6SKB

Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK3496783A

6SKB の概要

• エントリーDOI: 10.2210/pdb6skb/pdb
• 分子名称: Kallikrein-6, 4-[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, 4-[(3~{R})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, ... (5 entities in total)
• 機能のキーワード: protease, inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 96553.93

構造登録者

Thorpe, J.H. (登録日: 2019-08-15, 公開日: 2019-09-25, 最終更新日: 2024-01-24)

• 主引用文献: Walker, A.L.,Denis, A.,Bingham, R.P.,Boulliot, A.,Edgar, E.V.,Ferrie, A.,Holmes, D.S.,Laroze, A.,Liddle, J.,Fouchet, M.H.,Moquette, A.,Nassau, P.,Pearce, A.C.,Polyakova, O.,Smith, K.J.,Thomas, P.,Thorpe, J.H.,Trottet, L.,Wang, Y.,Hovnanian, A.; Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.; Bioorg.Med.Chem.Lett., 29:126675-126675, 2019; PubMed: 31521475; DOI: 10.1016/j.bmcl.2019.126675

実験手法

X-RAY DIFFRACTION (1.84 Å)