6SHI

Human kallikrein 7 with aromatic coumarinic ester compound 2 covalently bound to H57

6SHI の概要

• エントリーDOI: 10.2210/pdb6shi/pdb
• 分子名称: Kallikrein-7, TRIETHYLENE GLYCOL, 6-methyl-2-oxidanylidene-chromene-3-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: serine protease, covalent inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 206917.49

構造登録者

Hanke, S.,Straeter, N. (登録日: 2019-08-06, 公開日: 2020-05-20, 最終更新日: 2024-01-24)

• 主引用文献: Hanke, S.,Tindall, C.A.,Pippel, J.,Ulbricht, D.,Pirotte, B.,Reboud-Ravaux, M.,Heiker, J.T.,Strater, N.; Structural Studies on the Inhibitory Binding Mode of Aromatic Coumarinic Esters to Human Kallikrein-Related Peptidase 7.; J.Med.Chem., 63:5723-5733, 2020; PubMed: 32374603; DOI: 10.1021/acs.jmedchem.9b01806

実験手法

X-RAY DIFFRACTION (1.85 Å)