6SDT

HUMAN CARBONIC ANHYDRASE VII IN COMPLEX WITH A SULFONAMIDE INHIBITOR

6SDT の概要

• エントリーDOI: 10.2210/pdb6sdt/pdb
• 分子名称: Carbonic anhydrase 7, ZINC ION, phenyl-(4-sulfamoylphenoxy)phosphinic acid, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase vii, zinc enzyme, inhibitor, sulfonamide, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31304.37

構造登録者

Alterio, V.,De Simone, G.,Esposito, D. (登録日: 2019-07-29, 公開日: 2020-06-10, 最終更新日: 2024-01-24)

• 主引用文献: Nocentini, A.,Alterio, V.,Bua, S.,Micheli, L.,Esposito, D.,Buonanno, M.,Bartolucci, G.,Osman, S.M.,ALOthman, Z.A.,Cirilli, R.,Pierini, M.,Monti, S.M.,Di Cesare Mannelli, L.,Gratteri, P.,Ghelardini, C.,De Simone, G.,Supuran, C.T.; Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.; J.Med.Chem., 63:5185-5200, 2020; PubMed: 32364386; DOI: 10.1021/acs.jmedchem.9b02135

実験手法

X-RAY DIFFRACTION (1.94 Å)