6SDD
Crystal structure of D1228V cMET bound by BMS-777607
Summary for 6SDD
Entry DOI | 10.2210/pdb6sdd/pdb |
Descriptor | Hepatocyte growth factor receptor, N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35431.35 |
Authors | Collie, G.W.,Phillips, C. (deposition date: 2019-07-26, release date: 2019-08-14, Last modification date: 2024-05-15) |
Primary citation | Collie, G.W.,Koh, C.M.,O'Neill, D.J.,Stubbs, C.J.,Khurana, P.,Eddershaw, A.,Snijder, A.,Mauritzson, F.,Barlind, L.,Dale, I.L.,Shaw, J.,Phillips, C.,Hennessy, E.J.,Cheung, T.,Narvaez, A.J. Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors. Acs Med.Chem.Lett., 10:1322-1327, 2019 Cited by PubMed: 31531204DOI: 10.1021/acsmedchemlett.9b00276 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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