6SDD

Crystal structure of D1228V cMET bound by BMS-777607

6SDD の概要

• エントリーDOI: 10.2210/pdb6sdd/pdb
• 分子名称: Hepatocyte growth factor receptor, N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35431.35

構造登録者

Collie, G.W.,Phillips, C. (登録日: 2019-07-26, 公開日: 2019-08-14, 最終更新日: 2024-05-15)

• 主引用文献: Collie, G.W.,Koh, C.M.,O'Neill, D.J.,Stubbs, C.J.,Khurana, P.,Eddershaw, A.,Snijder, A.,Mauritzson, F.,Barlind, L.,Dale, I.L.,Shaw, J.,Phillips, C.,Hennessy, E.J.,Cheung, T.,Narvaez, A.J.; Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.; Acs Med.Chem.Lett., 10:1322-1327, 2019; PubMed: 31531204; DOI: 10.1021/acsmedchemlett.9b00276

実験手法

X-RAY DIFFRACTION (1.93 Å)