6S90

BTK in complex with an inhibitor

6S90 の概要

• エントリーDOI: 10.2210/pdb6s90/pdb
• 分子名称: Tyrosine-protein kinase BTK, 4-~{tert}-butyl-~{N}-[2-methyl-3-[6-[4-(4-methylpiperazin-1-yl)carbonylphenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]benzamide (3 entities in total)
• 機能のキーワード: btk, bruton tyrosine kinase, agammaglobulinaemia tyrosine kinase, atk, b-cell progenitor kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63415.01

構造登録者

Gutmann, S.,Hinniger, A. (登録日: 2019-07-11, 公開日: 2019-09-18, 最終更新日: 2024-05-15)

• 主引用文献: Pulz, R.,Angst, D.,Dawson, J.,Gessier, F.,Gutmann, S.,Hersperger, R.,Hinniger, A.,Janser, P.,Koch, G.,Revesz, L.,Vulpetti, A.,Waelchli, R.,Zimmerlin, A.,Cenni, B.; Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.; Acs Med.Chem.Lett., 10:1467-1472, 2019; PubMed: 31620235; DOI: 10.1021/acsmedchemlett.9b00317

実験手法

X-RAY DIFFRACTION (1.82 Å)