6S8I

Structure of ZEBOV GP in complex with 3T0265 antibody

6S8I の概要

• エントリーDOI: 10.2210/pdb6s8i/pdb
• EMDBエントリー: 10123
• 分子名称: Light Chain, Heavy Chain, Enveloped Glycoprotein 1, ... (5 entities in total)
• 機能のキーワード: ebola, glycoprotein, antibodies, viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 305961.01

構造登録者

Diskin, R.,Cohen-Dvashi, H. (登録日: 2019-07-10, 公開日: 2020-02-12, 最終更新日: 2024-10-23)

主引用文献

Cohen-Dvashi, H.,Zehner, M.,Ehrhardt, S.,Katz, M.,Elad, N.,Klein, F.,Diskin, R.
Structural Basis for a Convergent Immune Response against Ebola Virus.
Cell Host Microbe, 27:418-427.e4, 2020

PubMed Abstract: Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The V3-15/V1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three V3-15/V1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the V3-15/V1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of V3-15/V1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species.

PubMed: 32059794
DOI: 10.1016/j.chom.2020.01.007

実験手法

ELECTRON MICROSCOPY (2.99 Å)