6S7V

Lipoteichoic acids flippase LtaA

6S7V の概要

• エントリーDOI: 10.2210/pdb6s7v/pdb
• 分子名称: MFS transporter (1 entity in total)
• 機能のキーワード: lipoteichoic acids, flippase, transport protein
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42504.95

構造登録者

Zhang, B.,Perez, C. (登録日: 2019-07-06, 公開日: 2020-04-22, 最終更新日: 2024-05-15)

主引用文献

Zhang, B.,Liu, X.,Lambert, E.,Mas, G.,Hiller, S.,Veening, J.W.,Perez, C.
Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis.
Nat.Struct.Mol.Biol., 27:561-569, 2020

PubMed Abstract: Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria, including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell division and antibiotic resistance. Genetic evidence has suggested that LtaA is the flippase that mediates the translocation of the lipid-linked disaccharide that anchors LTA to the cell membrane, a rate-limiting step in S. aureus LTA biogenesis. Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter flippase that contributes to S. aureus survival under physiological acidic conditions. Our results provide foundations for the development of new strategies to counteract S. aureus infections.

PubMed: 32367070
DOI: 10.1038/s41594-020-0425-5

実験手法

X-RAY DIFFRACTION (3.301 Å)