6S6W

Crystal Structure of human ALDH1A3 in complex with 2,6-diphenylimidazo[1,2-a]pyridine (compound GA11) and NAD+

6S6W の概要

• エントリーDOI: 10.2210/pdb6s6w/pdb
• 分子名称: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: aldh1a3 ga11 glioma 2, 6-diphenylimidazo[1, 2-a]pyridine retinaldehyde dehydrogenase inhinitor aldhs, cytosolic protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109408.77

構造登録者

Gelardi, E.L.M.,Quattrini, L.,LaMotta, C.,Ferraris, D.M.,Garavaglia, S. (登録日: 2019-07-03, 公開日: 2020-04-22, 最終更新日: 2024-01-24)

• 主引用文献: Quattrini, L.,Gelardi, E.L.M.,Coviello, V.,Sartini, S.,Ferraris, D.M.,Mori, M.,Nakano, I.,Garavaglia, S.,La Motta, C.; Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.; J.Med.Chem., 63:4603-4616, 2020; PubMed: 32223240; DOI: 10.1021/acs.jmedchem.9b01910

実験手法