6S57
Crystal structure of human ATAD2 bromodomain in complex withN-(3-(azepan-1-ylsulfonyl)-4-methylphenyl)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)acetamide
6S57 の概要
エントリーDOI | 10.2210/pdb6s57/pdb |
分子名称 | ATPase family AAA domain-containing protein 2, 1,2-ETHANEDIOL, ~{N}-[3-(azepan-1-ylsulfonyl)-4-methyl-phenyl]-2-[4,4-dimethyl-2,5-bis(oxidanylidene)imidazolidin-1-yl]ethanamide, ... (5 entities in total) |
機能のキーワード | inhibitor, atad2, bromodomain, epigenetics, atpase family aaa domain-containing protein 2, transcription |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 16144.23 |
構造登録者 | |
主引用文献 | Bamborough, P.,Chung, C.W.,Demont, E.H.,Bridges, A.M.,Craggs, P.D.,Dixon, D.P.,Francis, P.,Furze, R.C.,Grandi, P.,Jones, E.J.,Karamshi, B.,Locke, K.,Lucas, S.C.C.,Michon, A.M.,Mitchell, D.J.,Pogany, P.,Prinjha, R.K.,Rau, C.,Roa, A.M.,Roberts, A.D.,Sheppard, R.J.,Watson, R.J. A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification. J.Med.Chem., 62:7506-7525, 2019 Cited by PubMed: 31398032DOI: 10.1021/acs.jmedchem.9b00673 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.82 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード