6S53

Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate

6S53 の概要

• エントリーDOI: 10.2210/pdb6s53/pdb
• 分子名称: Ubiquitin-conjugating enzyme E2 N, Polyubiquitin-C, E3 ubiquitin-protein ligase TRIM21, ... (6 entities in total)
• 機能のキーワード: e3 ubiquitin ligase, e2 conjugating enzyme, intracellular immunity, viral defence, trim21, ube2n, ubiquitin, ligase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 141491.91

構造登録者

Kiss, L.,Boland, A.,Neuhaus, D.,James, L.C. (登録日: 2019-06-30, 公開日: 2019-09-11, 最終更新日: 2024-01-24)

• 主引用文献: Kiss, L.,Zeng, J.,Dickson, C.F.,Mallery, D.L.,Yang, J.C.,McLaughlin, S.H.,Boland, A.,Neuhaus, D.,James, L.C.; A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.; Nat Commun, 10:4502-4502, 2019; PubMed: 31582740; DOI: 10.1038/s41467-019-12388-y

実験手法

X-RAY DIFFRACTION (2.8 Å)