6S4O
The crystal structure of glycogen phosphorylase in complex with 9
6S4O の概要
エントリーDOI | 10.2210/pdb6s4o/pdb |
分子名称 | Glycogen phosphorylase, muscle form, (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-(2-naphthalen-2-yl-1~{H}-imidazol-4-yl)oxane-3,4,5-triol, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total) |
機能のキーワード | phosphorylase, inhibitor, c-beta-d-glucopyranosyl imidazole, transferase |
由来する生物種 | Oryctolagus cuniculus (Rabbit) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 98374.12 |
構造登録者 | Kyriakis, E.,Solovou, T.G.A.,Papaioannou, O.S.E.,Skamnaki, V.T.,Leonidas, D.D. (登録日: 2019-06-28, 公開日: 2020-02-19) |
主引用文献 | Kyriakis, E.,Karra, A.G.,Papaioannou, O.,Solovou, T.,Skamnaki, V.T.,Liggri, P.G.V.,Zographos, S.E.,Szennyes, E.,Bokor, E.,Kun, S.,Psarra, A.G.,Somsak, L.,Leonidas, D.D. The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design. Bioorg.Med.Chem., 28:115196-115196, 2020 Cited by PubMed: 31767404DOI: 10.1016/j.bmc.2019.115196 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.35 Å) |
構造検証レポート
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