6S4I

Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin

Summary for 6S4I

Entry DOI	10.2210/pdb6s4i/pdb
Descriptor	Insulin, NITRATE ION, ... (4 entities in total)
Functional Keywords	insulin, oral, dimer, zinc free, hormone
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	5797.47
Authors	Johansson, E. (deposition date: 2019-06-28, release date: 2020-07-15, Last modification date: 2020-08-12)
Primary citation	Hubalek, F.,Refsgaard, H.H.F.,Gram-Nielsen, S.,Madsen, P.,Nishimura, E.,Munzel, M.,Brand, C.L.,Stidsen, C.E.,Claussen, C.H.,Wulff, E.M.,Pridal, L.,Ribel, U.,Kildegaard, J.,Porsgaard, T.,Johansson, E.,Steensgaard, D.B.,Hovgaard, L.,Glendorf, T.,Hansen, B.F.,Jensen, M.K.,Nielsen, P.K.,Ludvigsen, S.,Rugh, S.,Garibay, P.W.,Moore, M.C.,Cherrington, A.D.,Kjeldsen, T. Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11:3746-3746, 2020 Cited by PubMed: 32719315 DOI: 10.1038/s41467-020-17487-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.511 Å)

Structure validation