6S4F

Structure of human MTHFD2 in complex with TH9619

6S4F の概要

• エントリーDOI: 10.2210/pdb6s4f/pdb
• 分子名称: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70903.38

構造登録者

Scaletti, E.R.,Gustafsson, R.,Bonagas, N.,Gustafsson, N.M.,Henriksson, M.,Abdurakhmanov, E.,Andersson, Y.,Bengtsson, C.,Borhade, S.,Desroses, M.,Farnegardh, K.,Garg, N.,Gokturk, C.,Haraldsson, M.,Iliev, P.,Jarvius, M.,Jemth, A.S.,Kalderen, C.,Karsten, S.,Klingegard, F.,Koolmeister, T.,Martens, U.,Llona-Minguez, S.,Loseva, O.,Marttila, P.,Michel, M.,Moulson, R.,Nordstrom, H.,Paulin, C.,Pham, T.,Pudelko, L.,Rasti, A.,Roos, A.K.,Sarno, A.,Sandberg, L.,Scobie, M.,Sjoberg, B.,Svensson, R.,Unterlass, J.E.,Vallin, K.,Vo, D.,Wiita, E.,Warpman-Berglund, U.,Homan, E.J.,Helleday, T.,Stenmark, P. (登録日: 2019-06-27, 公開日: 2021-07-07, 最終更新日: 2023-04-12)

• 主引用文献: Bonagas, N.,Gustafsson, N.M.S.,Henriksson, M.,Marttila, P.,Gustafsson, R.,Wiita, E.,Borhade, S.,Green, A.C.,Vallin, K.S.A.,Sarno, A.,Svensson, R.,Gokturk, C.,Pham, T.,Jemth, A.S.,Loseva, O.,Cookson, V.,Kiweler, N.,Sandberg, L.,Rasti, A.,Unterlass, J.E.,Haraldsson, M.,Andersson, Y.,Scaletti, E.R.,Bengtsson, C.,Paulin, C.B.J.,Sanjiv, K.,Abdurakhmanov, E.,Pudelko, L.,Kunz, B.,Desroses, M.,Iliev, P.,Farnegardh, K.,Kramer, A.,Garg, N.,Michel, M.,Haggblad, S.,Jarvius, M.,Kalderen, C.,Jensen, A.B.,Almlof, I.,Karsten, S.,Zhang, S.M.,Haggblad, M.,Eriksson, A.,Liu, J.,Glinghammar, B.,Nekhotiaeva, N.,Klingegard, F.,Koolmeister, T.,Martens, U.,Llona-Minguez, S.,Moulson, R.,Nordstrom, H.,Parrow, V.,Dahllund, L.,Sjoberg, B.,Vargas, I.L.,Vo, D.D.,Wannberg, J.,Knapp, S.,Krokan, H.E.,Arvidsson, P.I.,Scobie, M.,Meiser, J.,Stenmark, P.,Berglund, U.W.,Homan, E.J.,Helleday, T.; Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.; Nat Cancer, 3:156-172, 2022; PubMed: 35228749; DOI: 10.1038/s43018-022-00331-y

実験手法

X-RAY DIFFRACTION (2.2 Å)