6S4B
Crystal Structure of BRD4(1) bound to inhibitor BUX1 (8)
Summary for 6S4B
Entry DOI | 10.2210/pdb6s4b/pdb |
Descriptor | Bromodomain-containing protein 4, (R,R)-2,3-BUTANEDIOL, ~{N}-[5-(diethylsulfamoyl)-2-methoxy-phenyl]-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide, ... (5 entities in total) |
Functional Keywords | brd4, brd4(1), inhibitor, bromodomain, epigenetic reader protein, acetylated, lysine, histone tail, protein binding-inhibitor complex, bux0, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15677.13 |
Authors | Huegle, M. (deposition date: 2019-06-27, release date: 2020-12-09, Last modification date: 2024-01-24) |
Primary citation | Hugle, M.,Regenass, P.,Warstat, R.,Hau, M.,Schmidtkunz, K.,Lucas, X.,Wohlwend, D.,Einsle, O.,Jung, M.,Breit, B.,Gunther, S. 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. J.Med.Chem., 63:15603-15620, 2020 Cited by PubMed: 33275431DOI: 10.1021/acs.jmedchem.0c00478 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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