6S4B

Crystal Structure of BRD4(1) bound to inhibitor BUX1 (8)

6S4B の概要

• エントリーDOI: 10.2210/pdb6s4b/pdb
• 分子名称: Bromodomain-containing protein 4, (R,R)-2,3-BUTANEDIOL, ~{N}-[5-(diethylsulfamoyl)-2-methoxy-phenyl]-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide, ... (5 entities in total)
• 機能のキーワード: brd4, brd4(1), inhibitor, bromodomain, epigenetic reader protein, acetylated, lysine, histone tail, protein binding-inhibitor complex, bux0, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15677.13

構造登録者

Huegle, M. (登録日: 2019-06-27, 公開日: 2020-12-09, 最終更新日: 2024-01-24)

• 主引用文献: Hugle, M.,Regenass, P.,Warstat, R.,Hau, M.,Schmidtkunz, K.,Lucas, X.,Wohlwend, D.,Einsle, O.,Jung, M.,Breit, B.,Gunther, S.; 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines.; J.Med.Chem., 63:15603-15620, 2020; PubMed: 33275431; DOI: 10.1021/acs.jmedchem.0c00478

実験手法

X-RAY DIFFRACTION (1.6 Å)