6S3A

Coxsackie B3 2C protein in complex with S-Fluoxetine

6S3A の概要

• エントリーDOI: 10.2210/pdb6s3a/pdb
• 分子名称: 2C protein, (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, ZINC ION, ... (5 entities in total)
• 機能のキーワード: 2c, enterovirus, helicase, atpase, complex, antiviral, porzac, fluoxetine, repurposing, coxsackievirus, viral protein
• 由来する生物種: Coxsackievirus B3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24173.55

構造登録者

El Kazzi, P.,Papageorgiou, N.,Ferron, F.P.,Bauer, L.,van Kuppeveld, F.,Coutard, B. (登録日: 2019-06-24, 公開日: 2021-01-13, 最終更新日: 2024-06-19)

• 主引用文献: Hurdiss, D.L.,El Kazzi, P.,Bauer, L.,Papageorgiou, N.,Ferron, F.P.,Donselaar, T.,van Vliet, A.L.W.,Shamorkina, T.M.,Snijder, J.,Canard, B.,Decroly, E.,Brancale, A.,Zeev-Ben-Mordehai, T.,Forster, F.,van Kuppeveld, F.J.M.,Coutard, B.; Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.; Sci Adv, 8:eabj7615-eabj7615, 2022; PubMed: 34985963; DOI: 10.1126/sciadv.abj7615

実験手法

X-RAY DIFFRACTION (1.52 Å)