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6S29

Structure of fission yeast Mis16-Mis19 complex

Summary for 6S29
Entry DOI10.2210/pdb6s29/pdb
DescriptorHistone acetyltransferase type B subunit 2, CENP-A recruiting complex protein mis19, BROMIDE ION, ... (4 entities in total)
Functional Keywordscentromere mitosis wd40 histone chaperone, cell cycle
Biological sourceSchizosaccharomyces pombe (Fission yeast)
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Total number of polymer chains4
Total formula weight111965.53
Authors
Lefevre, S.,Korntner-Vetter, M.,Singleton, M.R. (deposition date: 2019-06-20, release date: 2019-08-07, Last modification date: 2024-01-24)
Primary citationKorntner-Vetter, M.,Lefevre, S.,Hu, X.W.,George, R.,Singleton, M.R.
Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
Life Sci Alliance, 2:-, 2019
Cited by
PubMed Abstract: Centromeric chromatin in fission yeast is distinguished by the presence of nucleosomes containing the histone H3 variant Cnp1 Cell cycle-specific deposition of Cnp1 requires the Mis16-Mis18-Mis19 complex, which is thought to direct recruitment of Scm3-chaperoned Cnp1/histone H4 dimers to DNA. Here, we present the structure of the essential Mis18 partner protein Mis19 and describe its interaction with Mis16, revealing a bipartite-binding site. We provide data on the stoichiometry and overall architecture of the complex and provide detailed insights into the Mis18-Mis19 interface.
PubMed: 31371524
DOI: 10.26508/lsa.201900408
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.988 Å)
Structure validation

226707

건을2024-10-30부터공개중

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