6S29
Structure of fission yeast Mis16-Mis19 complex
Summary for 6S29
Entry DOI | 10.2210/pdb6s29/pdb |
Descriptor | Histone acetyltransferase type B subunit 2, CENP-A recruiting complex protein mis19, BROMIDE ION, ... (4 entities in total) |
Functional Keywords | centromere mitosis wd40 histone chaperone, cell cycle |
Biological source | Schizosaccharomyces pombe (Fission yeast) More |
Total number of polymer chains | 4 |
Total formula weight | 111965.53 |
Authors | Lefevre, S.,Korntner-Vetter, M.,Singleton, M.R. (deposition date: 2019-06-20, release date: 2019-08-07, Last modification date: 2024-01-24) |
Primary citation | Korntner-Vetter, M.,Lefevre, S.,Hu, X.W.,George, R.,Singleton, M.R. Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex. Life Sci Alliance, 2:-, 2019 Cited by PubMed Abstract: Centromeric chromatin in fission yeast is distinguished by the presence of nucleosomes containing the histone H3 variant Cnp1 Cell cycle-specific deposition of Cnp1 requires the Mis16-Mis18-Mis19 complex, which is thought to direct recruitment of Scm3-chaperoned Cnp1/histone H4 dimers to DNA. Here, we present the structure of the essential Mis18 partner protein Mis19 and describe its interaction with Mis16, revealing a bipartite-binding site. We provide data on the stoichiometry and overall architecture of the complex and provide detailed insights into the Mis18-Mis19 interface. PubMed: 31371524DOI: 10.26508/lsa.201900408 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.988 Å) |
Structure validation
Download full validation report