6S27

Crystal structure of human wild type STING in complex with 2'3'-cyclic-GMP-2'F-2'dAMP

Summary for 6S27

• Entry DOI: 10.2210/pdb6s27/pdb
• Descriptor: Stimulator of interferon protein, 2'3'-cyclic-GMP-2'F-2'dAMP (3 entities in total)
• Functional Keywords: activator, membrane protein, immune system, receptor, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23865.47

Authors

Smola, M.,Boura, E. (deposition date: 2019-06-20, release date: 2019-11-27, Last modification date: 2024-01-24)

• Primary citation: Novotna, B.,Vanekova, L.,Zavrel, M.,Budesinsky, M.,Dejmek, M.,Smola, M.,Gutten, O.,Tehrani, Z.A.,Pimkova Polidarova, M.,Brazdova, A.,Liboska, R.,Stepanek, I.,Vavrina, Z.,Jandusik, T.,Nencka, R.,Rulisek, L.,Boura, E.,Brynda, J.,Pav, O.,Birkus, G.; Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.; J.Med.Chem., 62:10676-10690, 2019; PubMed: 31715099; DOI: 10.1021/acs.jmedchem.9b01062

Experimental method

X-RAY DIFFRACTION (2.802 Å)