6S24

Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and the peptide 3

6S24 の概要

• エントリーDOI: 10.2210/pdb6s24/pdb
• 分子名称: Polypeptide N-acetylgalactosaminyltransferase, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (9 entities in total)
• 機能のキーワード: galnac-ts, galnac-t3, long-range glycosylation preference, (glyco)peptides, molecular dynamics, specificity, enzyme kinetics, fgf23, phosphate homeostasis, transferase
• 由来する生物種: Taeniopygia guttata (Zebra finch); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76035.18

構造登録者

de las Rivas, M.,Daniel, E.J.P.,Narimatsu, Y.,Companon, I.,Kato, K.,Hermosilla, P.,Thureau, A.,Ceballos-Laita, L.,Coelho, H.,Bernado, P.,Marcelo, F.,Hansen, L.,Lostao, A.,Corzana, F.,Clausen, H.,Gerken, T.A.,Hurtado-Guerrero, R. (登録日: 2019-06-20, 公開日: 2019-12-25, 最終更新日: 2024-01-24)

• 主引用文献: de Las Rivas, M.,Paul Daniel, E.J.,Narimatsu, Y.,Companon, I.,Kato, K.,Hermosilla, P.,Thureau, A.,Ceballos-Laita, L.,Coelho, H.,Bernado, P.,Marcelo, F.,Hansen, L.,Maeda, R.,Lostao, A.,Corzana, F.,Clausen, H.,Gerken, T.A.,Hurtado-Guerrero, R.; Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.; Nat.Chem.Biol., 16:351-360, 2020; PubMed: 31932717; DOI: 10.1038/s41589-019-0444-x

実験手法

X-RAY DIFFRACTION (2.12 Å)