6S1X

X-ray structure of human glutamate carboxypeptidase II (GCPII)-E424M inactive mutant, in complex with a inhibitor KB1160

6S1X の概要

• エントリーDOI: 10.2210/pdb6s1x/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; urea-based inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83425.31

構造登録者

Barinka, C.,Kutil, Z. (登録日: 2019-06-19, 公開日: 2020-05-13, 最終更新日: 2020-07-29)

• 主引用文献: Kim, K.,Kwon, H.,Barinka, C.,Motlova, L.,Nam, S.,Choi, D.,Ha, H.,Nam, H.,Son, S.H.,Minn, I.,Pomper, M.G.,Yang, X.,Kutil, Z.,Byun, Y.; Novel beta- and gamma-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen.; J.Med.Chem., 63:3261-3273, 2020; PubMed: 32097010; DOI: 10.1021/acs.jmedchem.9b02022

実験手法

X-RAY DIFFRACTION (1.76 Å)