6S1J

Crystal Structure of DYRK1A with small molecule inhibitor

Summary for 6S1J

• Entry DOI: 10.2210/pdb6s1j/pdb
• Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 3-[2-[(3~{S})-3-fluoranylpyrrolidin-1-yl]pyrimidin-4-yl]pyrazolo[1,5-b]pyridazine, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: kinase, catalytic domain, phosphorylated, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 43200.62

Authors

Sorrell, F.J.,Henderson, S.H.,Redondo, C.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Elkins, J.M. (deposition date: 2019-06-18, release date: 2019-06-26, Last modification date: 2024-01-24)

• Primary citation: Sorrell, F.J.,Henderson, S.H.,Elkins, J.M.,Ward, S.; Kinase Scaffold Repurposing in the Public Domain; To be published,

Experimental method

X-RAY DIFFRACTION (1.408 Å)