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6S1I

Crystal Structure of DYRK1A with small molecule inhibitor

Summary for 6S1I
Entry DOI10.2210/pdb6s1i/pdb
DescriptorDual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, TETRAETHYLENE GLYCOL, ... (5 entities in total)
Functional Keywordskinase, catalytic domain, phosphorylated, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight171179.04
Authors
Sorrell, F.J.,Henderson, S.H.,Redondo, C.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Elkins, J.M. (deposition date: 2019-06-18, release date: 2019-06-26, Last modification date: 2024-01-24)
Primary citationHenderson, S.H.,Sorrell, F.,Bennett, J.,Hanley, M.T.,Robinson, S.,Hopkins Navratilova, I.,Elkins, J.M.,Ward, S.E.
Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.
Acs Med.Chem.Lett., 11:1620-1626, 2020
Cited by
PubMed: 32832032
DOI: 10.1021/acsmedchemlett.0c00279
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.38 Å)
Structure validation

217705

건을2024-03-27부터공개중

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