6S1I
Crystal Structure of DYRK1A with small molecule inhibitor
Summary for 6S1I
Entry DOI | 10.2210/pdb6s1i/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, TETRAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | kinase, catalytic domain, phosphorylated, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 171179.04 |
Authors | Sorrell, F.J.,Henderson, S.H.,Redondo, C.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Elkins, J.M. (deposition date: 2019-06-18, release date: 2019-06-26, Last modification date: 2024-01-24) |
Primary citation | Henderson, S.H.,Sorrell, F.,Bennett, J.,Hanley, M.T.,Robinson, S.,Hopkins Navratilova, I.,Elkins, J.M.,Ward, S.E. Mining Public Domain Data to Develop Selective DYRK1A Inhibitors. Acs Med.Chem.Lett., 11:1620-1626, 2020 Cited by PubMed: 32832032DOI: 10.1021/acsmedchemlett.0c00279 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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