6S1F
Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3
Summary for 6S1F
Entry DOI | 10.2210/pdb6s1f/pdb |
Descriptor | Receptor-interacting serine/threonine-protein kinase 2, ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide (3 entities in total) |
Functional Keywords | ripk2 cslp3, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 147357.64 |
Authors | Pinkas, D.M.,Bufton, J.C.,Kupinska, K.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2019-06-18, release date: 2019-10-16, Last modification date: 2024-01-24) |
Primary citation | Suebsuwong, C.,Dai, B.,Pinkas, D.M.,Bufton, J.C.,Duddupudi, A.L.,Li, L.,Hrdinka, M.,Schlicher, L.,Gyrd-Hansen, M.,Hu, M.,Bullock, A.N.,Degterev, A.,Cuny, G.D. Design of 3,5-diaryl-2-aminopyridines as receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors To be published, |
Experimental method | X-RAY DIFFRACTION (3.11 Å) |
Structure validation
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