6S1F

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3

Summary for 6S1F

• Entry DOI: 10.2210/pdb6s1f/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 2, ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide (3 entities in total)
• Functional Keywords: ripk2 cslp3, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 147357.64

Authors

Pinkas, D.M.,Bufton, J.C.,Kupinska, K.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2019-06-18, release date: 2019-10-16, Last modification date: 2024-01-24)

• Primary citation: Suebsuwong, C.,Dai, B.,Pinkas, D.M.,Bufton, J.C.,Duddupudi, A.L.,Li, L.,Hrdinka, M.,Schlicher, L.,Gyrd-Hansen, M.,Hu, M.,Bullock, A.N.,Degterev, A.,Cuny, G.D.; Design of 3,5-diaryl-2-aminopyridines as receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (3.11 Å)