6S14
Crystal Structure of DYRK1A with small molecule inhibitor
Summary for 6S14
Entry DOI | 10.2210/pdb6s14/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, ~{N}-cyclopropyl-~{N}-methyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | kinase, catalytic domain, phosphorylated, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42924.21 |
Authors | Sorrell, F.J.,Henderson, S.H.,Redondo, C.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Elkins, J.M. (deposition date: 2019-06-18, release date: 2019-06-26, Last modification date: 2024-01-24) |
Primary citation | Sorrell, F.J.,Henderson, S.H.,Elkins, J.M.,Ward, S. Kinase Scaffold Repurposing in the Public Domain To be published, |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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