6S0W

The crystal structure of kanamycin B dioxygenase (KanJ) from Streptomyces kanamyceticus in complex with nickel and kanamycin B sulfate

6S0W の概要

• エントリーDOI: 10.2210/pdb6s0w/pdb
• 分子名称: Kanamycin B dioxygenase, (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, NICKEL (II) ION, ... (6 entities in total)
• 機能のキーワード: non-heme iron dioxygenase, alpha-ketoglutarate dioxygenase, kanamycin biosynthesis, kanj, oxidoreductase, kanamycin b, metal binding protein
• 由来する生物種: Streptomyces kanamyceticus
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 196231.16

構造登録者

Mrugala, B.,Niedzialkowska, E.,Minor, W.,Borowski, T. (登録日: 2019-06-18, 公開日: 2020-07-08, 最終更新日: 2024-01-24)

• 主引用文献: Mrugala, B.,Milaczewska, A.,Porebski, P.J.,Niedzialkowska, E.,Guzik, M.,Minor, W.,Borowski, T.; A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates.; Febs J., 288:1366-1386, 2021; PubMed: 32592631; DOI: 10.1111/febs.15462

実験手法

X-RAY DIFFRACTION (2.36 Å)