6RXQ

Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16Cr-2'OH-ADPr peptide intermediate after soaking

Summary for 6RXQ

Entry DOI	10.2210/pdb6rxq/pdb
Descriptor	NAD-dependent protein deacylase, Histone H4, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-4-[(~{E})-but-2-enoxy]-3,5-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate, ... (4 entities in total)
Functional Keywords	deacylase, nad-dependent, nad, intermediate, crotonyl, lysine, hydrolase
Biological source	Escherichia coli (strain K12) More
Total number of polymer chains	8
Total formula weight	119750.59
Authors	Spinck, M.,Gasper, R.,Neumann, H. (deposition date: 2019-06-08, release date: 2020-04-15, Last modification date: 2024-01-24)
Primary citation	Spinck, M.,Neumann-Staubitz, P.,Ecke, M.,Gasper, R.,Neumann, H. Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59:11142-11149, 2020 Cited by PubMed: 32187803 DOI: 10.1002/anie.202002899 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation