6RVD

Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex

6RVD の概要

• エントリーDOI: 10.2210/pdb6rvd/pdb
• EMDBエントリー: 8955
• 分子名称: Protein patched homolog 1, Sonic hedgehog protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: ---- hedgehog morphogen receptor, receptor-nanobody complex, cholesterol, palmitate, lipid-protein-modification, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 344944.31

構造登録者

El Omari, K.,Rudolf, A.F.,Kowatsch, C.,Malinauskas, T.,Kinnebrew, M.,Ansell, T.B.,Bishop, B.,Pardon, E.,Schwab, R.A.,Qian, M.,Duman, R.,Covey, D.F.,Steyaert, J.,Wagner, A.,Sansom, M.S.P.,Rohatgi, R.,Siebold, C. (登録日: 2019-05-31, 公開日: 2019-10-02, 最終更新日: 2020-07-29)

• 主引用文献: Rudolf, A.F.,Kinnebrew, M.,Kowatsch, C.,Ansell, T.B.,El Omari, K.,Bishop, B.,Pardon, E.,Schwab, R.A.,Malinauskas, T.,Qian, M.,Duman, R.,Covey, D.F.,Steyaert, J.,Wagner, A.,Sansom, M.S.P.,Rohatgi, R.,Siebold, C.; The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.; Nat.Chem.Biol., 15:975-982, 2019; PubMed: 31548691; DOI: 10.1038/s41589-019-0370-y

実験手法

ELECTRON MICROSCOPY (3.5 Å)