6RVC

Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75

Summary for 6RVC

• Entry DOI: 10.2210/pdb6rvc/pdb
• Descriptor: Protein patched homolog 1, Nanobody NB75, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: ---- hedgehog morphogen receptor, receptor-nanobody complex, cholesterol, palmitate, lipid-protein-modification, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 136976.89

Authors

Rudolf, A.F.,Kowatsch, C.,El Omari, K.,Malinauskas, T.,Kinnebrew, M.,Ansell, T.B.,Bishop, B.,Pardon, E.,Schwab, R.A.,Qian, M.,Duman, R.,Covey, D.F.,Steyaert, J.,Wagner, A.,Sansom, M.S.P.,Rohatgi, R.,Siebold, C. (deposition date: 2019-05-31, release date: 2019-10-02, Last modification date: 2024-01-24)

• Primary citation: Rudolf, A.F.,Kinnebrew, M.,Kowatsch, C.,Ansell, T.B.,El Omari, K.,Bishop, B.,Pardon, E.,Schwab, R.A.,Malinauskas, T.,Qian, M.,Duman, R.,Covey, D.F.,Steyaert, J.,Wagner, A.,Sansom, M.S.P.,Rohatgi, R.,Siebold, C.; The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.; Nat.Chem.Biol., 15:975-982, 2019; PubMed: 31548691; DOI: 10.1038/s41589-019-0370-y

Experimental method

X-RAY DIFFRACTION (2.2 Å)