6RV3

Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493

Summary for 6RV3

• Entry DOI: 10.2210/pdb6rv3/pdb
• Descriptor: Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ... (7 entities in total)
• Functional Keywords: membrane protein, potassium channel, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 129475.35

Authors

Rodstrom, K.E.J.,Pike, A.C.W.,Zhang, W.,Quigley, A.,Speedman, D.,Mukhopadhyay, S.M.M.,Shrestha, L.,Chalk, R.,Venkaya, S.,Bushell, S.R.,Tessitore, A.,Burgess-Brown, N.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2019-05-30, release date: 2019-08-07, Last modification date: 2024-01-24)

• Primary citation: Rodstrom, K.E.J.,Kiper, A.K.,Zhang, W.,Rinne, S.,Pike, A.C.W.,Goldstein, M.,Conrad, L.J.,Delbeck, M.,Hahn, M.G.,Meier, H.,Platzk, M.,Quigley, A.,Speedman, D.,Shrestha, L.,Mukhopadhyay, S.M.M.,Burgess-Brown, N.A.,Tucker, S.J.,Muller, T.,Decher, N.,Carpenter, E.P.; A lower X-gate in TASK channels traps inhibitors within the vestibule.; Nature, 582:443-447, 2020; PubMed: 32499642; DOI: 10.1038/s41586-020-2250-8

Experimental method

X-RAY DIFFRACTION (2.9 Å)