6RV3
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493
6RV3 の概要
エントリーDOI | 10.2210/pdb6rv3/pdb |
分子名称 | Potassium channel subfamily K member 3, POTASSIUM ION, CHOLESTEROL HEMISUCCINATE, ... (7 entities in total) |
機能のキーワード | membrane protein, potassium channel, structural genomics, structural genomics consortium, sgc |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 129475.35 |
構造登録者 | Rodstrom, K.E.J.,Pike, A.C.W.,Zhang, W.,Quigley, A.,Speedman, D.,Mukhopadhyay, S.M.M.,Shrestha, L.,Chalk, R.,Venkaya, S.,Bushell, S.R.,Tessitore, A.,Burgess-Brown, N.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (登録日: 2019-05-30, 公開日: 2019-08-07, 最終更新日: 2024-01-24) |
主引用文献 | Rodstrom, K.E.J.,Kiper, A.K.,Zhang, W.,Rinne, S.,Pike, A.C.W.,Goldstein, M.,Conrad, L.J.,Delbeck, M.,Hahn, M.G.,Meier, H.,Platzk, M.,Quigley, A.,Speedman, D.,Shrestha, L.,Mukhopadhyay, S.M.M.,Burgess-Brown, N.A.,Tucker, S.J.,Muller, T.,Decher, N.,Carpenter, E.P. A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582:443-447, 2020 Cited by PubMed: 32499642DOI: 10.1038/s41586-020-2250-8 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
構造検証レポート
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