6RRN

GOLGI ALPHA-MANNOSIDASE II in complex with pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide

6RRN の概要

• エントリーDOI: 10.2210/pdb6rrn/pdb
• 分子名称: Alpha-mannosidase 2, 1,2-ETHANEDIOL, SUCCINIC ACID, ... (6 entities in total)
• 機能のキーワード: mannosidase, glycoside hydrolase, hydrolase
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 119072.28

構造登録者

Armstrong, Z.,Lahav, D.,Johnson, R.,Kuo, C.L.,Beenakker, T.J.M.,de Boer, C.,Wong, C.S.,van Rijssel, E.R.,Debets, M.,Geurink, P.P.,Ovaa, H.,van der Stelt, M.,Codee, J.D.C.,Aerts, J.M.F.G.,Wu, L.,Overkleeft, H.S.,Davies, G.J. (登録日: 2019-05-20, 公開日: 2020-07-08, 最終更新日: 2024-01-24)

• 主引用文献: Armstrong, Z.,Kuo, C.L.,Lahav, D.,Liu, B.,Johnson, R.,Beenakker, T.J.M.,de Boer, C.,Wong, C.S.,van Rijssel, E.R.,Debets, M.F.,Florea, B.I.,Hissink, C.,Boot, R.G.,Geurink, P.P.,Ovaa, H.,van der Stelt, M.,van der Marel, G.M.,Codee, J.D.C.,Aerts, J.M.F.G.,Wu, L.,Overkleeft, H.S.,Davies, G.J.; Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.; J.Am.Chem.Soc., 142:13021-13029, 2020; PubMed: 32605368; DOI: 10.1021/jacs.0c03880

実験手法

X-RAY DIFFRACTION (1.59 Å)