6RPG
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor
Summary for 6RPG
Entry DOI | 10.2210/pdb6rpg/pdb |
Descriptor | Programmed cell death 1 ligand 1, ~{N}-[2-[[4-[[3-[3-[[4-[(2-acetamidoethylamino)methyl]-5-[(5-cyanopyridin-3-yl)methoxy]-2-methyl-phenoxy]methyl]-2-methyl-phenyl]-2-methyl-phenyl]methoxy]-2-[(5-cyanopyridin-3-yl)methoxy]-5-methyl-phenyl]methylamino]ethyl]ethanamide (3 entities in total) |
Functional Keywords | complex, inhibitor, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 30272.61 |
Authors | Magiera-Mularz, K.,Basu, S.,Yang, J.,Xu, B.,Skalniak, L.,Musielak, B.,Kholodovych, V.,Holak, T.A.,Hu, L. (deposition date: 2019-05-14, release date: 2019-07-24, Last modification date: 2024-01-24) |
Primary citation | Basu, S.,Yang, J.,Xu, B.,Magiera-Mularz, K.,Skalniak, L.,Musielak, B.,Kholodovych, V.,Holak, T.A.,Hu, L. Design, Synthesis, Evaluation, and Structural Studies ofC2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction. J.Med.Chem., 62:7250-7263, 2019 Cited by PubMed: 31298541DOI: 10.1021/acs.jmedchem.9b00795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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