6RNU

BCL-XL in a complex with a covalent small molecule inhibitor

Summary for 6RNU

Entry DOI	10.2210/pdb6rnu/pdb
Descriptor	Bcl-2-like protein 1, 4-(4-fluorophenyl)-3-fluorosulfonyl-benzoic acid, BROMIDE ION, ... (4 entities in total)
Functional Keywords	bcl-xl, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	41445.17
Authors	Hargreaves, D. (deposition date: 2019-05-09, release date: 2019-10-02, Last modification date: 2019-11-20)
Primary citation	Mukherjee, H.,Su, N.,Belmonte, M.A.,Hargreaves, D.,Patel, J.,Tentarelli, S.,Aquila, B.,Grimster, N.P. Discovery and optimization of covalent Bcl-xL antagonists. Bioorg.Med.Chem.Lett., 29:126682-126682, 2019 Cited by PubMed: 31606346 DOI: 10.1016/j.bmcl.2019.126682 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation