6RNL
L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT)
Summary for 6RNL
| Entry DOI | 10.2210/pdb6rnl/pdb |
| Descriptor | DNA (5'-D(*TP*AP*GP*GP*GP*TP*T)-3'), POTASSIUM ION, Ru(tap)2(dppz) complex, ... (5 entities in total) |
| Functional Keywords | ruthenium, intercalation, dna, asymmetric |
| Biological source | synthetic construct |
| Total number of polymer chains | 4 |
| Total formula weight | 11765.89 |
| Authors | McQuaid, K.T.,Hall, J.P.,Cardin, C.J. (deposition date: 2019-05-09, release date: 2019-08-28, Last modification date: 2024-05-15) |
| Primary citation | McQuaid, K.,Hall, J.P.,Baumgaertner, L.,Cardin, D.J.,Cardin, C.J. Three thymine/adenine binding modes of the ruthenium complex Lambda-[Ru(TAP)2(dppz)]2+to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography. Chem.Commun.(Camb.), 55:9116-9119, 2019 Cited by PubMed Abstract: Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed from terminal T·A and T·T mismatched pairs. A third shows kinking by a TAP ligand between T·T linkages, while the fourth shows sandwiching of a dppz ligand between a T·A/T·A quadruplex and a T·T mismatch, stabilised by an additional T·A base pair stacking interaction on a TAP surface. Overall, the structure shows an unexpected affinity for thymine, and suggests models for G-quadruplex loop binding. PubMed: 31298665DOI: 10.1039/c9cc04316k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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