6RLZ

Crystal Structure of 14-3-3zeta in complex with a macrocyclic 8-mer peptide derived from ExoS

6RLZ の概要

• エントリーDOI: 10.2210/pdb6rlz/pdb
• 分子名称: 14-3-3 protein zeta/delta, EtMe (3 entities in total)
• 機能のキーワード: protein-protein-interaction macrocycle peptide, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 54459.75

構造登録者

Wallraven, K.,Grossmann, T.N.,Hennig, S. (登録日: 2019-05-03, 公開日: 2020-03-18, 最終更新日: 2020-03-25)

• 主引用文献: Wallraven, K.,Holmelin, F.L.,Glas, A.,Hennig, S.,Frolov, A.I.,Grossmann, T.N.; Adapting free energy perturbation simulations for large macrocyclic ligands: how to dissect contributions from direct binding and free ligand flexibility.; Chem Sci, 11:2269-2276, 2020; PubMed: 32180932; DOI: 10.1039/c9sc04705k

実験手法

X-RAY DIFFRACTION (3.7 Å)