6RLG

Crystal structure of LdtMt2 from Mycobacterium tuberculosis

6RLG の概要

• エントリーDOI: 10.2210/pdb6rlg/pdb
• 分子名称: L,D-transpeptidase 2, NITRATE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total)
• 機能のキーワード: beta lactmase, antibiotic resistance, tuberculosis, antimicrobial protein
• 由来する生物種: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77245.58

構造登録者

Brem, J.,Lohans, C.,Schofield, C. (登録日: 2019-05-02, 公開日: 2019-08-14, 最終更新日: 2024-01-24)

主引用文献

de Munnik, M.,Lohans, C.T.,Lang, P.A.,Langley, G.W.,Malla, T.R.,Tumber, A.,Schofield, C.J.,Brem, J.
Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2with cysteine-reactive inhibitors including ebselen.
Chem.Commun.(Camb.), 55:10214-10217, 2019

PubMed Abstract: The l,d-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against LdtMt2 from Mycobacterium tuberculosis. Structural studies on LdtMt2 with potent inhibitor ebselen reveal opening of the benzisoselenazolone ring by a nucleophilic cysteine, forming a complex involving extensive hydrophobic interactions with a substrate-binding loop.

PubMed: 31380528
DOI: 10.1039/c9cc04145a

実験手法

X-RAY DIFFRACTION (1.51000183032 Å)