6R9X

Human Cyclophilin D in complex with N-cyclopentyl-N'-pyridin-2-ylmethyl-oxalamide

6R9X の概要

• エントリーDOI: 10.2210/pdb6r9x/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase F, mitochondrial, ~{N}'-cyclopentyl-~{N}-(pyridin-2-ylmethyl)ethanediamide (3 entities in total)
• 機能のキーワード: cyclophilin, beta barrel, prolyl cis/trans isomerase, mitoc, isomerase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17899.42

構造登録者

Graedler, U. (登録日: 2019-04-04, 公開日: 2019-11-27, 最終更新日: 2024-01-24)

• 主引用文献: Gradler, U.,Schwarz, D.,Blaesse, M.,Leuthner, B.,Johnson, T.L.,Bernard, F.,Jiang, X.,Marx, A.,Gilardone, M.,Lemoine, H.,Roche, D.,Jorand-Lebrun, C.; Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.; Bioorg.Med.Chem.Lett., 29:126717-126717, 2019; PubMed: 31635932; DOI: 10.1016/j.bmcl.2019.126717

実験手法

X-RAY DIFFRACTION (1.66 Å)