6R99

Crystal Structure of Human CLN protein 5 (Ceroid Lipofuscinosis Neuronal Protein 5)

Summary for 6R99

Entry DOI	10.2210/pdb6r99/pdb
Descriptor	Ceroid-lipofuscinosis neuronal protein 5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	neuronal ceroid lipofiscinosis, cln5, circularly-permuted papain-like fold, glycoprotein, unknown function
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	48359.10
Authors	Luebben, A.V.,Sheldrick, G.M. (deposition date: 2019-04-03, release date: 2020-04-22, Last modification date: 2022-09-28)
Primary citation	Luebben, A.V.,Bender, D.,Becker, S.,Crowther, L.M.,Erven, I.,Hofmann, K.,Soding, J.,Klemp, H.,Bellotti, C.,Stauble, A.,Qiu, T.,Kathayat, R.S.,Dickinson, B.C.,Gartner, J.,Sheldrick, G.M.,Kratzner, R.,Steinfeld, R. Cln5 represents a new type of cysteine-based S -depalmitoylase linked to neurodegeneration. Sci Adv, 8:eabj8633-eabj8633, 2022 Cited by PubMed: 35427157 DOI: 10.1126/sciadv.abj8633 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation