6R99
Crystal Structure of Human CLN protein 5 (Ceroid Lipofuscinosis Neuronal Protein 5)
Summary for 6R99
Entry DOI | 10.2210/pdb6r99/pdb |
Descriptor | Ceroid-lipofuscinosis neuronal protein 5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | neuronal ceroid lipofiscinosis, cln5, circularly-permuted papain-like fold, glycoprotein, unknown function |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 48359.10 |
Authors | Luebben, A.V.,Sheldrick, G.M. (deposition date: 2019-04-03, release date: 2020-04-22, Last modification date: 2022-09-28) |
Primary citation | Luebben, A.V.,Bender, D.,Becker, S.,Crowther, L.M.,Erven, I.,Hofmann, K.,Soding, J.,Klemp, H.,Bellotti, C.,Stauble, A.,Qiu, T.,Kathayat, R.S.,Dickinson, B.C.,Gartner, J.,Sheldrick, G.M.,Kratzner, R.,Steinfeld, R. Cln5 represents a new type of cysteine-based S -depalmitoylase linked to neurodegeneration. Sci Adv, 8:eabj8633-eabj8633, 2022 Cited by PubMed: 35427157DOI: 10.1126/sciadv.abj8633 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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