6R99

Crystal Structure of Human CLN protein 5 (Ceroid Lipofuscinosis Neuronal Protein 5)

6R99 の概要

• エントリーDOI: 10.2210/pdb6r99/pdb
• 分子名称: Ceroid-lipofuscinosis neuronal protein 5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: neuronal ceroid lipofiscinosis, cln5, circularly-permuted papain-like fold, glycoprotein, unknown function
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48359.10

構造登録者

Luebben, A.V.,Sheldrick, G.M. (登録日: 2019-04-03, 公開日: 2020-04-22, 最終更新日: 2022-09-28)

• 主引用文献: Luebben, A.V.,Bender, D.,Becker, S.,Crowther, L.M.,Erven, I.,Hofmann, K.,Soding, J.,Klemp, H.,Bellotti, C.,Stauble, A.,Qiu, T.,Kathayat, R.S.,Dickinson, B.C.,Gartner, J.,Sheldrick, G.M.,Kratzner, R.,Steinfeld, R.; Cln5 represents a new type of cysteine-based S -depalmitoylase linked to neurodegeneration.; Sci Adv, 8:eabj8633-eabj8633, 2022; PubMed: 35427157; DOI: 10.1126/sciadv.abj8633

実験手法

X-RAY DIFFRACTION (2.7 Å)