6R7X

CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)

6R7X の概要

• エントリーDOI: 10.2210/pdb6r7x/pdb
• EMDBエントリー: 4746
• 分子名称: Anoctamin-10, CALCIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (4 entities in total)
• 機能のキーワード: membrane protein, calcium activation, transport protein, lipid transport, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 166304.57

構造登録者

Pike, A.C.W.,Bushell, S.R.,Shintre, C.A.,Tessitore, A.,Baronina, A.,Chu, A.,Mukhopadhyay, S.,Shrestha, L.,Chalk, R.,Burgess-Brown, N.A.,Love, J.,Huiskonen, J.T.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (登録日: 2019-03-29, 公開日: 2019-05-01, 最終更新日: 2019-12-18)

• 主引用文献: Bushell, S.R.,Pike, A.C.W.,Falzone, M.E.,Rorsman, N.J.G.,Ta, C.M.,Corey, R.A.,Newport, T.D.,Christianson, J.C.,Scofano, L.F.,Shintre, C.A.,Tessitore, A.,Chu, A.,Wang, Q.,Shrestha, L.,Mukhopadhyay, S.M.M.,Love, J.D.,Burgess-Brown, N.A.,Sitsapesan, R.,Stansfeld, P.J.,Huiskonen, J.T.,Tammaro, P.,Accardi, A.,Carpenter, E.P.; The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.; Nat Commun, 10:3956-3956, 2019; PubMed: 31477691; DOI: 10.1038/s41467-019-11753-1

実験手法

ELECTRON MICROSCOPY (3.47 Å)