6R7K

Ligand complex of RORg LBD

Summary for 6R7K

• Entry DOI: 10.2210/pdb6r7k/pdb
• Descriptor: Nuclear receptor ROR-gamma, SRC2 peptide, (2~{R})-2-(4-ethylsulfonylphenyl)-~{N}-[4-[1,1,1,3,3,3-hexakis(fluoranyl)-2-oxidanyl-propan-2-yl]phenyl]-2-(2-phenylethanoylamino)ethanamide, ... (6 entities in total)
• Functional Keywords: rar-related orphan receptor-g (rorg), transcription, rorg ligand, structure-based design
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 35451.61

Authors

Xue, Y.,Aagaard, A.,Narjes, F.,von Berg, S. (deposition date: 2019-03-29, release date: 2019-07-03, Last modification date: 2024-05-15)

• Primary citation: von Berg, S.,Xue, Y.,Collins, M.,Llinas, A.,Olsson, R.I.,Halvarsson, T.,Lindskog, M.,Malmberg, J.,Jirholt, J.,Krutrok, N.,Ramnegard, M.,Brannstrom, M.,Lundqvist, A.,Lepisto, M.,Aagaard, A.,McPheat, J.,Hansson, E.L.,Chen, R.,Xiong, Y.,Hansson, T.G.,Narjes, F.; Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2.; Acs Med.Chem.Lett., 10:972-977, 2019; PubMed: 31223457; DOI: 10.1021/acsmedchemlett.9b00158

Experimental method

X-RAY DIFFRACTION (1.54 Å)