6R6F

Crystal structure of human carbonic anhydrase isozyme II with 4-chloro-2-cyclohexylsulfanyl-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide

6R6F の概要

• エントリーDOI: 10.2210/pdb6r6f/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-chloranyl-2-cyclohexylsulfanyl-~{N}-(2-hydroxyethyl)-5-sulfamoyl-benzamide, ... (5 entities in total)
• 機能のキーワード: drug design, carbonic anhydrase, benzenesulfonamide, metal binding protein, lyase-lyase inhibitor complex, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29825.53

構造登録者

Smirnov, A.,Manakova, E.,Grazulis, S. (登録日: 2019-03-27, 公開日: 2019-12-18, 最終更新日: 2024-01-24)

• 主引用文献: Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Paketuryte, V.,Smirnov, A.,Leitans, J.,Kazaks, A.,Dvinskis, E.,Manakova, E.,Grazulis, S.,Tars, K.,Matulis, D.; Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.; Eur.J.Med.Chem., 185:111825-111825, 2020; PubMed: 31740053; DOI: 10.1016/j.ejmech.2019.111825

実験手法

X-RAY DIFFRACTION (1.2 Å)