6R66
Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue
Summary for 6R66
| Entry DOI | 10.2210/pdb6r66/pdb |
| Descriptor | Transthyretin, 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid (3 entities in total) |
| Functional Keywords | amyloidosis, tetramer, binding protein, transport protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 32460.29 |
| Authors | Loconte, V.,Menozzi, I.,Ferrari, A.,Berni, R.,Zanotti, G. (deposition date: 2019-03-26, release date: 2019-09-11, Last modification date: 2019-11-06) |
| Primary citation | Loconte, V.,Menozzi, I.,Ferrari, A.,Folli, C.,Imbimbo, B.P.,Zanotti, G.,Berni, R. Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. J.Struct.Biol., 208:165-173, 2019 Cited by PubMed: 31473362DOI: 10.1016/j.jsb.2019.08.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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